First-Trimester Urine Concentrations of Phthalate Metabolites and Phenols and Placenta miRNA Expression in a Cohort of U.S. Women | Zendy

Jessica LaRocca | Zendy; Alexandra M. Binder | Zendy; Thomas F. McElrath | Zendy; Karin B. Michels | Zendy

Open Access

First-Trimester Urine Concentrations of Phthalate Metabolites and Phenols and Placenta miRNA Expression in a Cohort of U.S. Women

Author(s) -

Jessica LaRocca,

Alexandra M. Binder,

Thomas F. McElrath,

Karin B. Michels

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408409

Subject(s) - phthalate , epigenetics , microrna , placenta , biology , tolerable daily intake , andrology , pregnancy , physiology , endocrinology , medicine , chemistry , fetus , gene , genetics , organic chemistry , body weight

There is increasing concern that early-life exposure to endocrine-disrupting chemicals (EDCs) can influence the risk of disease development. Phthalates and phenols are two classes of suspected EDCs that are used in a variety of everyday consumer products, including plastics, epoxy resins, and cosmetics. In utero exposure to EDCs may affect disease propensity through epigenetic mechanisms.

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