Cadmium and Proliferation in Human Uterine Leiomyoma Cells: Evidence of a Role for EGFR/MAPK Pathways but Not Classical Estrogen Receptor Pathways | Zendy

Xiaohua Gao | Zendy; Linda ChiaHui Yu | Zendy; Alicia B. Moore | Zendy; Grace E. Kissling | Zendy; Michael P. Waalkes | Zendy; Darlene Dixon | Zendy

Open Access

Cadmium and Proliferation in Human Uterine Leiomyoma Cells: Evidence of a Role for EGFR/MAPK Pathways but Not Classical Estrogen Receptor Pathways

Author(s) -

Xiaohua Gao,

Linda ChiaHui Yu,

Alicia B. Moore,

Grace E. Kissling,

Michael P. Waalkes,

Darlene Dixon

Publication year - 2014

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1408234

Subject(s) - estrogen receptor , transactivation , mapk/erk pathway , cell growth , estrogen , endocrinology , biology , medicine , uterine leiomyoma , signal transduction , chemistry , microbiology and biotechnology , cancer research , uterus , cancer , gene expression , biochemistry , breast cancer , gene

It has been proposed that cadmium (Cd) is an environmental "metalloestrogen" and that its action is mediated via the estrogen receptor (ER). Cd mimics the effects of estrogen in the rat uterus, and blood Cd concentrations positively correlate with ER levels in uteri of women with fibroids.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research