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Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells
Author(s) -
Amy L. Strong,
Zhenzhen Shi,
Michael J. Strong,
David F. Miller,
Douglas B. Rusch,
Aaron Buechlein,
Erik K. Flemington,
John A. McLachlan,
Kenneth P. Nephew,
Matthew E. Burow,
Bruce A. Bunnell
Publication year - 2014
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1408188
Subject(s) - mesenchymal stem cell , biology , stem cell , adipogenesis , microbiology and biotechnology , cellular differentiation , osteonectin , peroxisome proliferator activated receptor , estrogen receptor , endocrinology , cancer research , receptor , alkaline phosphatase , gene , genetics , biochemistry , cancer , breast cancer , osteocalcin , enzyme
Although the global use of the endocrine-disrupting chemical DDT has decreased, its persistence in the environment has resulted in continued human exposure. Accumulating evidence suggests that DDT exposure has long-term adverse effects on development, yet the impact on growth and differentiation of adult stem cells remains unclear.

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