Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse | Zendy

Weihsueh A. Chiu | Zendy; Jerry L. Campbell | Zendy; Harvey J. Clewell | Zendy; Yi-Hui Zhou | Zendy; Fred A. Wright | Zendy; Kathryn Z. Guyton | Zendy; Ivan Rusyn | Zendy

Open Access

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Author(s) -

Weihsueh A. Chiu,

Jerry L. Campbell,

Harvey J. Clewell,

Yi-Hui Zhou,

Fred A. Wright,

Kathryn Z. Guyton,

Ivan Rusyn

Publication year - 2014

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1307623

Subject(s) - physiologically based pharmacokinetic modelling , toxicokinetics , population , glutathione , dichloroacetic acid , metabolism , trichloroethylene , chemistry , pharmacokinetics , biology , toxicology , environmental chemistry , pharmacology , biochemistry , medicine , environmental health , enzyme

Quantitative estimation of toxicokinetic variability in the human population is a persistent challenge in risk assessment of environmental chemicals. Traditionally, interindividual differences in the population are accounted for by default assumptions or, in rare cases, are based on human toxicokinetic data.

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