Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ER α  Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers ( DNMT3A , MBD2 , and HDAC2 ) in the Mouse Seminal Vesicle  | Zendy

Yin Li | Zendy; Katherine J. Hamilton | Zendy; Anne Y. Lai | Zendy; Katherine A. Burns | Zendy; Leping Li | Zendy; Paul A. Wade | Zendy; Kenneth S. Korach | Zendy

Open Access

Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ER α Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers ( DNMT3A , MBD2 , and HDAC2 ) in the Mouse Seminal Vesicle

Author(s) -

Yin Li,

Katherine J. Hamilton,

Anne Y. Lai,

Katherine A. Burns,

Leping Li,

Paul A. Wade,

Kenneth S. Korach

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1307351

Subject(s) - epigenetics , diethylstilbestrol , methylation , dna methylation , gene , biology , hormone , genetics , gene expression , endocrinology

Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes.

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