Comparing Models: DBP Effects in Rat and Human Germ Cells | Zendy

Julia R. Barrett | Zendy

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Comparing Models: DBP Effects in Rat and Human Germ Cells

Author(s) -

Julia R. Barrett

Publication year - 2015

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.123-a69

Subject(s) - germ cell , biology , sperm , phthalate , andrology , leydig cell , endocrinology , sertoli cell , medicine , fetus , testicle , spermatogenesis , hormone , chemistry , pregnancy , genetics , luteinizing hormone , gene , organic chemistry

Prenatal exposure to di(n-butyl) phthalate (DBP), a chemical that makes plastics flexible, has been associated with a spectrum of male reproductive system disorders in animals,1 and there is evidence it may adversely affect human testicular germ cells.2 A new study in EHP provides new evidence regarding mechanisms of DBP-related effects in germ cells and suggests that a rat model may be suitable for studying effects of DBP on human germ cells.3

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