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High Bioavailability of Bisphenol A from Sublingual Exposure
Author(s) -
Véronique Gayrard,
Marlène Z. Lacroix,
Séverine H. Collet,
Catherine Viguié,
Alain Bousquetmélou,
PierreLouis Toutain,
Nicole PicardHagen
Publication year - 2013
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1206339
Subject(s) - bioavailability , sublingual administration , gastrointestinal tract , absorption (acoustics) , ingestion , benzhydryl compounds , pharmacology , oral administration , pharmacokinetics , bisphenol a , chemistry , route of administration , medicine , endocrinology , organic chemistry , epoxy , physics , acoustics
Bisphenol A (BPA) risk assessment is currently hindered by the rejection of reported higher-than-expected plasma BPA concentrations in humans after oral ingestion. These are deemed incompatible with the almost complete hepatic first-pass metabolism of BPA into its inactive glucurono-conjugated form, BPA glucuronide (BPAG).

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