Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenicin Utero | Zendy

Devin C. Koestler | Zendy; Michele Avissar-Whiting | Zendy; E. Andrés Houseman | Zendy; Margaret R. Karagas | Zendy; Carmen J. Marsit | Zendy

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Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenicin Utero

Author(s) -

Devin C. Koestler,

Michele Avissar-Whiting,

E. Andrés Houseman,

Margaret R. Karagas,

Carmen J. Marsit

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205925

Subject(s) - dna methylation , in utero , cord blood , cpg site , methylation , umbilical cord , offspring , epigenetics , physiology , dnam , biology , arsenic , andrology , urinary system , pregnancy , immunology , medicine , fetus , genetics , endocrinology , chemistry , dna , gene expression , organic chemistry , gene

There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations, specifically by altering patterns of DNA methylation.

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