Relative Effect Potency Estimates of Dioxin-like Activity for Dioxins, Furans, and Dioxin-like PCBs in Adults Based on Two Thyroid Outcomes | Zendy

T. Trnovec | Zendy; Todd A. Jusko | Zendy; Eva Šovˇcíková | Zendy; Kinga Lancz | Zendy; Jana Chovancová | Zendy; Henrieta Patayová | Zendy; L’ubica Palkoviˇcová | Zendy; Beata Drobná | Zendy; P Langer | Zendy; Martin van den Berg | Zendy; Ladislav Dedı́k | Zendy; Soňa Wimmerová | Zendy

Open Access

Relative Effect Potency Estimates of Dioxin-like Activity for Dioxins, Furans, and Dioxin-like PCBs in Adults Based on Two Thyroid Outcomes

Author(s) -

T. Trnovec,

Todd A. Jusko,

Eva Šovˇcíková,

Kinga Lancz,

Jana Chovancová,

Henrieta Patayová,

L’ubica Palkoviˇcová,

Beata Drobná,

P Langer,

Martin van den Berg,

Ladislav Dedı́k,

Soňa Wimmerová

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205739

Subject(s) - thyroid , ingestion , potency , in vivo , physiology , chemistry , reference dose , toxicology , medicine , environmental health , endocrinology , risk assessment , biology , in vitro , microbiology and biotechnology , biochemistry , computer security , computer science

Toxic equivalency factors (TEFs) are an important component in the risk assessment of dioxin-like human exposures. At present, this concept is based mainly on in vivo animal experiments using oral dosage. Consequently, the current human TEFs derived from mammalian experiments are applicable only for exposure situations in which oral ingestion occurs. Nevertheless, these "intake" TEFs are commonly-but incorrectly-used by regulatory authorities to calculate "systemic" toxic equivalents (TEQs) based on human blood and tissue concentrations, which are used as biomarkers for either exposure or effect.

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