Systems Biology and Birth Defects Prevention: Blockade of the Glucocorticoid Receptor Prevents Arsenic-Induced Birth Defects | Zendy

Bhavesh K. Ahir | Zendy; Alison P. Sanders | Zendy; Julia E. Rager | Zendy; Rebecca C. Fry | Zendy

Open Access

Systems Biology and Birth Defects Prevention: Blockade of the Glucocorticoid Receptor Prevents Arsenic-Induced Birth Defects

Author(s) -

Bhavesh K. Ahir,

Alison P. Sanders,

Julia E. Rager,

Rebecca C. Fry

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205659

Subject(s) - glucocorticoid receptor , teratology , biological pathway , biology , developmental toxicity , glucocorticoid , in silico , signal transduction , microbiology and biotechnology , bioinformatics , fetus , genetics , immunology , gene , pregnancy , gene expression

The biological mechanisms by which environmental metals are associated with birth defects are largely unknown. Systems biology-based approaches may help to identify key pathways that mediate metal-induced birth defects as well as potential targets for prevention.

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