Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates | Zendy

Julia E. Rager | Zendy; Benjamin C. Moeller | Zendy; Melanie DoyleEisele | Zendy; Dean Kracko | Zendy; James A. Swenberg | Zendy; Rebecca C. Fry | Zendy

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Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates

Author(s) -

Julia E. Rager,

Benjamin C. Moeller,

Melanie DoyleEisele,

Dean Kracko,

James A. Swenberg,

Rebecca C. Fry

Publication year - 2013

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205582

Subject(s) - epigenetics , microrna , formaldehyde , biology , epithelium , medicine , physiology , genetics , gene , biochemistry

Formaldehyde is an air pollutant present in both indoor and outdoor atmospheres. Because of its ubiquitous nature, it is imperative to understand the mechanisms underlying formaldehyde-induced toxicity and carcinogenicity. MicroRNAs (miRNAs) can influence disease caused by environmental exposures, yet miRNAs are understudied in relation to formaldehyde. Our previous investigation demonstrated that formaldehyde exposure in human lung cells caused disruptions in miRNA expression profiles in vitro.

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