Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6 | Zendy

Maria Luisa Feo | Zendy; Michael S. Gross | Zendy; Barbara P. McGarrigle | Zendy; Ethel Eljarrat | Zendy; ‪Damià Barceló | Zendy; Diana S. Aga | Zendy; James R. Olson | Zendy

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Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6

Author(s) -

Maria Luisa Feo,

Michael S. Gross,

Barbara P. McGarrigle,

Ethel Eljarrat,

‪Damià Barceló,

Diana S. Aga,

James R. Olson

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205446

Subject(s) - biotransformation , metabolite , cyp2b6 , chemistry , toxicology , environmental chemistry , pharmacology , medicine , biology , cytochrome p450 , metabolism , biochemistry , enzyme , cyp3a4

Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more toxic than the parent PBDEs. However, the specific enzymes responsible for the formation of OH-PBDEs are unknown.

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