Coplanar Polychlorinated Biphenyls Impair Glucose Homeostasis in Lean C57BL/6 Mice and Mitigate Beneficial Effects of Weight Loss on Glucose Homeostasis in Obese Mice | Zendy

Nicki A. Baker | Zendy; Michael Karounos | Zendy; Victoria English | Zendy; Jun Fang | Zendy; Yinan Wei | Zendy; Arnold J. Stromberg | Zendy; Manjula Sunkara | Zendy; Andrew J. Morris | Zendy; Hollie I. Swanson | Zendy; Lisa A. Cassis | Zendy

Open Access

Coplanar Polychlorinated Biphenyls Impair Glucose Homeostasis in Lean C57BL/6 Mice and Mitigate Beneficial Effects of Weight Loss on Glucose Homeostasis in Obese Mice

Author(s) -

Nicki A. Baker,

Michael Karounos,

Victoria English,

Jun Fang,

Yinan Wei,

Arnold J. Stromberg,

Manjula Sunkara,

Andrew J. Morris,

Hollie I. Swanson,

Lisa A. Cassis

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205421

Subject(s) - adipose tissue , medicine , glucose homeostasis , endocrinology , insulin resistance , proinflammatory cytokine , insulin , homeostasis , glucose tolerance test , in vivo , tumor necrosis factor alpha , chemistry , biology , inflammation , microbiology and biotechnology

Previous studies demonstrated that coplanar polychlorinated biphenyls (PCBs) promote proinflammatory gene expression in adipocytes. PCBs are highly lipophilic and accumulate in adipose tissue, a site of insulin resistance in persons with type 2 diabetes.

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