Genetic Modification of the Association between Peripubertal Dioxin Exposure and Pubertal Onset in a Cohort of Russian Boys | Zendy

Olivier Humblet | Zendy; Susan Korrick | Zendy; Paige L. Williams | Zendy; Oleg Sergeyev | Zendy; Claude Emond | Zendy; Linda S. Birnbaum | Zendy; Jane S. Burns | Zendy; Larisa Altshul | Zendy; Donald G. Patterson | Zendy; Wayman E. Turner | Zendy; Mary Lee | Zendy; Boris Revich | Zendy; Russ Hauser | Zendy

Open Access

Genetic Modification of the Association between Peripubertal Dioxin Exposure and Pubertal Onset in a Cohort of Russian Boys

Author(s) -

Olivier Humblet,

Susan Korrick,

Paige L. Williams,

Oleg Sergeyev,

Claude Emond,

Linda S. Birnbaum,

Jane S. Burns,

Larisa Altshul,

Donald G. Patterson,

Wayman E. Turner,

Mary Lee,

Boris Revich,

Russ Hauser

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205278

Subject(s) - single nucleotide polymorphism , glucocorticoid receptor , biology , estrogen receptor , genetic association , candidate gene , endocrinology , medicine , estrogen , genome wide association study , estrogen receptor alpha , genetics , gene , glucocorticoid , genotype , cancer , breast cancer

Exposure to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies. Whether genetic polymorphisms may modify this association is currently unknown. Identifying such genes could provide insight into mechanistic pathways. This is one of the first studies to assess genetic susceptibility to dioxins.

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