Bisphenol A Diglycidyl Ether Induces Adipogenic Differentiation of Multipotent Stromal Stem Cells through a Peroxisome Proliferator–Activated Receptor Gamma-Independent Mechanism | Zendy

Raquel Chamorro-García | Zendy; Séverine Kirchner | Zendy; Xia Li | Zendy; Amanda Janesick | Zendy; Stephanie C. Casey | Zendy; Connie Chow | Zendy; Bruce Blumberg | Zendy

Open Access

Bisphenol A Diglycidyl Ether Induces Adipogenic Differentiation of Multipotent Stromal Stem Cells through a Peroxisome Proliferator–Activated Receptor Gamma-Independent Mechanism

Author(s) -

Raquel Chamorro-García,

Séverine Kirchner,

Xia Li,

Amanda Janesick,

Stephanie C. Casey,

Connie Chow,

Bruce Blumberg

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1205063

Subject(s) - adipogenesis , mesenchymal stem cell , peroxisome proliferator activated receptor , stromal cell , microbiology and biotechnology , chemistry , 3t3 l1 , biology , endocrinology , medicine , receptor , cancer research , biochemistry

Bisphenol A (BPA) and bisphenol A diglycidyl ether (BADGE), used in manufacturing coatings and resins, leach from packaging materials into food. Numerous studies suggested that BPA and BADGE may have adverse effects on human health, including the possibility that exposure to such chemicals can be superimposed on traditional risk factors to initiate or exacerbate the development of obesity. BPA is a suspected obesogen, whereas BADGE, described as a peroxisome proliferator-activated receptor gamma (PPARγ) antagonist, could reduce weight gain.

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