Oxidatively Damaged DNA in Rats Exposed by Oral Gavage to C 60 Fullerenes and Single-Walled Carbon Nanotubes
Author(s) -
Janne K. Folkmann,
Lotte Risom,
Nicklas Raun Jacobsen,
Håkan Wallin,
Steffen Loft,
Peter Möller
Publication year - 2008
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.11922
Subject(s) - genotoxicity , oxidative stress , dna damage , fullerene , comet assay , chemistry , corn oil , oral administration , pharmacology , saline , biochemistry , dna , toxicity , food science , medicine , organic chemistry
C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event in the development of cancer.
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