Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats | Zendy

Dongren Yang | Zendy; KyungHo Kim | Zendy; Andrew Phimister | Zendy; Adam D. Bachstetter | Zendy; Thomas R. Ward | Zendy; Robert W. Stackman | Zendy; Ronald F. Mervis | Zendy; Amy B. Wisniewski | Zendy; Sabra L. Klein | Zendy; Prasada Rao S. Kodavanti | Zendy; Kim A. Anderson | Zendy; Gary A. Wayman | Zendy; Isaac N. Pessah | Zendy; Pamela J. Lein | Zendy

Open Access

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

Author(s) -

Dongren Yang,

KyungHo Kim,

Andrew Phimister,

Adam D. Bachstetter,

Thomas R. Ward,

Robert W. Stackman,

Ronald F. Mervis,

Amy B. Wisniewski,

Sabra L. Klein,

Prasada Rao S. Kodavanti,

Kim A. Anderson,

Gary A. Wayman,

Isaac N. Pessah,

Pamela J. Lein

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11771

Subject(s) - ryanodine receptor , dendritic spine , weanling , neuroscience , neuroplasticity , cerebellum , biology , morris water navigation task , environmental enrichment , medicine , receptor , endocrinology , hippocampus , genetics , hippocampal formation

Neurodevelopmental disorders are associated with altered patterns of neuronal connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of individual neurons, which is shaped by experience. The identification of environmental exposures that interfere with dendritic growth and plasticity may, therefore, provide insight into environmental risk factors for neurodevelopmental disorders.

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