Long-Term Effects on Hypothalamic Neuropeptides after Developmental Exposure to Chlorpyrifos in Mice
Author(s) -
Sabrina Tait,
Laura Ricceri,
Aldina Venerosi,
Francesca Maranghi,
Alberto Mantovani,
Gemma Calamandrei
Publication year - 2008
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.11696
Subject(s) - offspring , endocrinology , medicine , oxytocin , vasopressin , neuropeptide , hypothalamus , prolactin , acetylcholinesterase , biology , developmental toxicity , fetus , hormone , pregnancy , receptor , enzyme , biochemistry , genetics
Increasing evidence from animal and human studies indicates that chlorpyrifos (CPF), similar to other organophosphorus insecticides still widely used, is a developmental neurotoxicant. Developmental exposure to CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social and agonistic responses, which suggests that CPF may interfere with maturation of neuroendocrine mechanisms.
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