DDT Exposure of Zebrafish Embryos Enhances Seizure Susceptibility: Relationship to Fetal p,p ′-DDE Burden and Domoic Acid Exposure of California Sea Lions | Zendy

Jessica A. Tiedeken | Zendy; John S. Ramsdell | Zendy

Open Access

DDT Exposure of Zebrafish Embryos Enhances Seizure Susceptibility: Relationship to Fetal p,p ′-DDE Burden and Domoic Acid Exposure of California Sea Lions

Author(s) -

Jessica A. Tiedeken,

John S. Ramsdell

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11685

Subject(s) - domoic acid , zebrafish , biology , embryo , physiology , zoology , fishery , genetics , gene , toxin

California sea lions have a large body burden of organochlorine pesticides, and over the last decade they have also been subject to domoic acid poisoning. Domoic acid poisoning, previously recognized in adult animals, is now viewed as a major cause of prenatal mortality. The appearance of a chronic juvenile domoic acid disease in the sea lions, characterized by behavioral abnormalities and epilepsy, is consistent with early life poisoning and may be potentiated by organochlorine burden.

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