Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval | Zendy

Sung Kyun Park | Zendy; Howard Hu | Zendy; Robert O. Wright | Zendy; Joel Schwartz | Zendy; Yawen Cheng | Zendy; David Sparrow | Zendy; Pantel Vokonas | Zendy; Marc G. Weisskopf | Zendy

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Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval

Author(s) -

Sung Kyun Park,

Howard Hu,

Robert O. Wright,

Joel Schwartz,

Yawen Cheng,

David Sparrow,

Pantel Vokonas,

Marc G. Weisskopf

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11559

Subject(s) - interquartile range , qt interval , medicine , confidence interval , genotype , cardiology , endocrinology , bioinformatics , genetics , biology , gene

Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance the oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (HFE), transferrin (TF) C2, and heme oxygenase-1 (HMOX-1)] increase susceptibility to the effects of lead on QT interval in 613 community-dwelling older men.

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