Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response | Zendy

Yu Du | Zendy; Nicole Villeneuve | Zendy; Xiaojun Wang | Zendy; Zheng Sun | Zendy; Weimin Chen | Zendy; Jixue Li | Zendy; HongXiang Lou | Zendy; Pak Kin Wong | Zendy; Donna D. Zhang | Zendy

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Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response

Author(s) -

Yu Du,

Nicole Villeneuve,

Xiaojun Wang,

Zheng Sun,

Weimin Chen,

Jixue Li,

HongXiang Lou,

Pak Kin Wong,

Donna D. Zhang

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11464

Subject(s) - keap1 , arsenic toxicity , arsenic , toxicity , transcription factor , reactive oxygen species , activator (genetics) , chemistry , signal transduction , microbiology and biotechnology , pharmacology , biology , biochemistry , organic chemistry , gene

Groundwater contaminated with arsenic imposes a big challenge to human health worldwide. Using natural compounds to subvert the detrimental effects of arsenic represents an attractive strategy. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical regulator of the cellular antioxidant response and xenobiotic metabolism. Recently, activation of the Nrf2 signaling pathway has been reported to confer protection against arsenic-induced toxicity in a cell culture model.

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