Transcriptome Analysis in Peripheral Blood of Humans Exposed to Environmental Carcinogens: A Promising New Biomarker in Environmental Health Studies | Zendy

Danitsja M. van Leeuwen | Zendy; Ralph W.H. Gottschalk | Zendy; Greet Schoeters | Zendy; Nicolas Van Larebeke | Zendy; Vera Nelen | Zendy; Willy Baeyens | Zendy; Jos Kleinjans | Zendy; Joost H.M. van Delft | Zendy

Open Access

Transcriptome Analysis in Peripheral Blood of Humans Exposed to Environmental Carcinogens: A Promising New Biomarker in Environmental Health Studies

Author(s) -

Danitsja M. van Leeuwen,

Ralph W.H. Gottschalk,

Greet Schoeters,

Nicolas Van Larebeke,

Vera Nelen,

Willy Baeyens,

Jos Kleinjans,

Joost H.M. van Delft

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11401

Subject(s) - biology , toxicogenomics , transcriptome , gene expression , biomarker , carcinogenesis , carcinogen , gene , gene expression profiling , genetics

Human carcinogenesis is known to be initiated and/or promoted by exposure to chemicals that occur in the environment. Molecular cancer epidemiology is used to identify human environmental cancer risks by applying a range of effect biomarkers, which tend to be nonspecific and do not generate insights into underlying modes of action. Toxicogenomic technologies may improve on this by providing the opportunity to identify molecular biomarkers consisting of altered gene expression profiles.

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