Murine Lung Responses to Ambient Particulate Matter: Genomic Analysis and Influence on Airway Hyperresponsiveness | Zendy

Ting Wang | Zendy; Liliana MorenoVinasco | Zendy; Yong Huang | Zendy; Gabriel Lang | Zendy; Jered D. Linares | Zendy; Sascha N. Goonewardena | Zendy; Alayna Grabavoy | Zendy; Jonathan M. Samet | Zendy; Alison S. Geyh | Zendy; Patrick N. Breysse | Zendy; Yves A. Lussier | Zendy; Viswanathan Natarajan | Zendy; Joe G. N. Garcia | Zendy

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Murine Lung Responses to Ambient Particulate Matter: Genomic Analysis and Influence on Airway Hyperresponsiveness

Author(s) -

Ting Wang,

Liliana MorenoVinasco,

Yong Huang,

Gabriel Lang,

Jered D. Linares,

Sascha N. Goonewardena,

Alayna Grabavoy,

Jonathan M. Samet,

Alison S. Geyh,

Patrick N. Breysse,

Yves A. Lussier,

Viswanathan Natarajan,

Joe G. N. Garcia

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11229

Subject(s) - immunology , bronchoalveolar lavage , eosinophil , ovalbumin , eotaxin , proinflammatory cytokine , asthma , medicine , inflammation , tumor necrosis factor alpha , lung , immune system

Asthma is a complex disease characterized by airway hyperresponsiveness (AHR) and chronic airway inflammation. Epidemiologic studies have demonstrated that exposures to environmental factors such as ambient particulate matter (PM), a major air pollutant, contribute to increased asthma prevalence and exacerbations.

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