Genomic Profiling Reveals an Alternate Mechanism for Hepatic Tumor Promotion by Perfluorooctanoic Acid in Rainbow Trout | Zendy

Susan C. Tilton | Zendy; Gayle A. Orner | Zendy; Abby D. Benninghoff | Zendy; Hillary M. Carpenter | Zendy; Jerry D. Hendricks | Zendy; Cliff Pereira | Zendy; David E. Williams | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genomic Profiling Reveals an Alternate Mechanism for Hepatic Tumor Promotion by Perfluorooctanoic Acid in Rainbow Trout

Author(s) -

Susan C. Tilton,

Gayle A. Orner,

Abby D. Benninghoff,

Hillary M. Carpenter,

Jerry D. Hendricks,

Cliff Pereira,

David E. Williams

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11190

Subject(s) - carcinogenesis , trout , endocrinology , medicine , biology , peroxisome , tumor promotion , perfluorooctanoic acid , gene , biochemistry , fishery , fish <actinopterygii>

Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are considered refractory to carcinogenesis by PPs. Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research