Identification of the Functional Domain of Thyroid Hormone Receptor Responsible for Polychlorinated Biphenyl–Mediated Suppression of Its Action in Vitro | Zendy

Wataru Miyazaki | Zendy; Toshiharu Iwasaki | Zendy; Akira Takeshita | Zendy; Chiharu Tohyama | Zendy; Noriyuki Koibuchi | Zendy

Open Access

Identification of the Functional Domain of Thyroid Hormone Receptor Responsible for Polychlorinated Biphenyl–Mediated Suppression of Its Action in Vitro

Author(s) -

Wataru Miyazaki,

Toshiharu Iwasaki,

Akira Takeshita,

Chiharu Tohyama,

Noriyuki Koibuchi

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11176

Subject(s) - polychlorinated biphenyl , receptor , chemistry , nuclear receptor , thyroid hormone receptor , thyroid , reporter gene , aryl hydrocarbon receptor , hormone , transcription factor , medicine , endocrinology , biology , biochemistry , gene , environmental chemistry , gene expression

Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and poly-chlorinated dibenzofurans adversely affect the health of humans and various animals. Such effects might be partially exerted through the thyroid hormone (TH) system. We previously reported that one of the hydroxylated PCB congeners suppresses TH receptor (TR)-mediated transcription by dissociating TR from the TH response element (TRE). However, the binding site of PCB within TR has not yet been identified.

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