Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production | Zendy

Romain Lambrot | Zendy; Vincent Muczynski | Zendy; Charlotte Lécureuil | Zendy; Gaëlle Angenard | Zendy; Hervé Coffigny | Zendy; Catherine Pairault | Zendy; Delphine Moison | Zendy; René Frydman | Zendy; René Habert | Zendy; Virginie RouillerFabre | Zendy

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Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production

Author(s) -

Romain Lambrot,

Vincent Muczynski,

Charlotte Lécureuil,

Gaëlle Angenard,

Hervé Coffigny,

Catherine Pairault,

Delphine Moison,

René Frydman,

René Habert,

Virginie RouillerFabre

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11146

Subject(s) - medicine , endocrinology , phthalate , testosterone (patch) , sertoli cell , biology , germ cell , endocrine disruptor , anogenital distance , luteinizing hormone , endocrine system , fetus , hormone , apoptosis , andrology , spermatogenesis , in utero , chemistry , pregnancy , biochemistry , genetics , organic chemistry , gene

Several studies have described an increasing frequency of male reproductive disorders, which may have a common origin in fetal life and which are hypothesized to be caused by endocrine disruptors. Phthalate esters represent a class of environmental endocrine-active chemicals known to disrupt development of the male reproductive tract by decreasing testosterone production in the fetal rat.

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