Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells | Zendy

Milou M.L. Dingemans | Zendy; Aart de Groot | Zendy; Regina G.D.M. van Kleef | Zendy; Åke Bergman | Zendy; Martin van den Berg | Zendy; Henk P.M. Vijverberg | Zendy; Remco H.S. Westerink | Zendy

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Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells

Author(s) -

Milou M.L. Dingemans,

Aart de Groot,

Regina G.D.M. van Kleef,

Åke Bergman,

Martin van den Berg,

Henk P.M. Vijverberg,

Remco H.S. Westerink

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.11059

Subject(s) - chemistry , metabolite , catecholamine , extracellular , thapsigargin , endoplasmic reticulum , protonophore , calcium , intracellular , fura 2 , homeostasis , exocytosis , polybrominated diphenyl ethers , calcium metabolism , metabolism , calcium in biology , biochemistry , biophysics , endocrinology , mitochondrion , cytosol , biology , secretion , enzyme , organic chemistry , pollutant

Oxidative metabolism, resulting in the formation of hydroxylated polybrominated diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated flame retardants.

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