Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes | Zendy

Rui Zhao | Zendy; Yongyong Hou | Zendy; Qiang Zhang | Zendy; Courtney G. Woods | Zendy; Peng Xue | Zendy; Jingqi Fu | Zendy; Kathy Yarborough | Zendy; Dawei Guan | Zendy; Melvin E. Andersen | Zendy; Jingbo Pi | Zendy

Open Access

Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes

Author(s) -

Rui Zhao,

Yongyong Hou,

Qiang Zhang,

Courtney G. Woods,

Peng Xue,

Jingqi Fu,

Kathy Yarborough,

Dawei Guan,

Melvin E. Andersen,

Jingbo Pi

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104580

Subject(s) - keap1 , hacat , gene silencing , nrf1 , oxidative stress , microbiology and biotechnology , chemistry , gene knockdown , transcription factor , biology , biochemistry , apoptosis , in vitro , gene

Nuclear factor E2-related factors (NRFs), including NRF2 and NRF1, play critical roles in mediating the cellular adaptive response to oxidative stress. Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer.

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