Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts | Zendy

Marco Pupo | Zendy; Assunta Pisano | Zendy; Rosamaria Lappano | Zendy; Maria Francesca Santolla | Zendy; Ernestina Marianna De Francesco | Zendy; Sergio Abonante | Zendy; Camillo Rosano | Zendy; Marcello Maggiolini | Zendy

Open Access

Bisphenol A Induces Gene Expression Changes and Proliferative Effects through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts

Author(s) -

Marco Pupo,

Assunta Pisano,

Rosamaria Lappano,

Maria Francesca Santolla,

Ernestina Marianna De Francesco,

Sergio Abonante,

Camillo Rosano,

Marcello Maggiolini

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104526

Subject(s) - gper , breast cancer , cancer , cancer research , gene expression , carcinogen , gene , biology , medicine , cancer cell , endocrinology , genetics , estrogen receptor

Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ERα and ERβ) and through the G protein-coupled receptor (GPR30/GPER). In this regard, recent studies have shown that GPER was involved in the proliferative effects induced by BPA in both normal and tumor cells.

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