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Particulate Matter, DNA Methylation in Nitric Oxide Synthase, and Childhood Respiratory Disease
Author(s) -
Carrie V. Breton,
Muhammad T. Salam,
Xinhui Wang,
HyangMin Byun,
Kimberly D. Siegmund,
Frank D. Gilliland
Publication year - 2012
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1104439
Subject(s) - dna methylation , cpg site , methylation , exhaled nitric oxide , nitric oxide synthase , wheeze , pyrosequencing , epigenetics , nitric oxide , biology , immunology , medicine , asthma , endocrinology , genetics , gene expression , dna , gene , bronchoconstriction
Air pollutants have been associated with childhood asthma and wheeze. Epigenetic regulation of nitric oxide synthase--the gene responsible for nitric oxide production--may be affected by air pollutants and contribute to the pathogenesis of asthma and wheeze.

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