Accelerated Mammary Tumor Onset in a HER2/ Neu Mouse Model Exposed to DDT Metabolites Locally Delivered to the Mammary Gland | Zendy

Nakpangi Johnson | Zendy; Arline Ho | Zendy; J. Mark Cline | Zendy; Claude L. Hughes | Zendy; Warren G. Foster | Zendy; Vicki L. Davis | Zendy

Open Access

Accelerated Mammary Tumor Onset in a HER2/ Neu Mouse Model Exposed to DDT Metabolites Locally Delivered to the Mammary Gland

Author(s) -

Nakpangi Johnson,

Arline Ho,

J. Mark Cline,

Claude L. Hughes,

Warren G. Foster,

Vicki L. Davis

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104327

Subject(s) - adipose tissue , medicine , endocrinology , mammary gland , metabolite , endocrine system , carcinogen , breast cancer , biology , hormone , chemistry , cancer , genetics

The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attention has been focused on estrogenic congeners, we tested the cancer-inducing potential of the antiandrogen, p,p´-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene], the most prevalent and persistent DDT metabolite.

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