The Organochlorine o,p’ -DDT Plays a Role in Coactivator-Mediated MAPK Crosstalk in MCF-7 Breast Cancer Cells | Zendy

Melyssa R. Bratton | Zendy; Daniel E. Frigo | Zendy; H. Chris Segar | Zendy; Kenneth P. Nephew | Zendy; John A. McLachlan | Zendy; Thomas Wiese | Zendy; Matthew E. Burow | Zendy

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The Organochlorine o,p’ -DDT Plays a Role in Coactivator-Mediated MAPK Crosstalk in MCF-7 Breast Cancer Cells

Author(s) -

Melyssa R. Bratton,

Daniel E. Frigo,

H. Chris Segar,

Kenneth P. Nephew,

John A. McLachlan,

Thomas Wiese,

Matthew E. Burow

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104296

Subject(s) - coactivator , estrogen receptor , biology , mcf 7 , gene expression , estrogen receptor alpha , endocrine disruptor , signal transduction , regulation of gene expression , cancer research , creb , crosstalk , microbiology and biotechnology , cancer cell , transcription factor , endocrinology , gene , cancer , breast cancer , genetics , endocrine system , hormone , human breast , physics , optics

The organochlorine dichlorodiphenyltrichloroethane (DDT), a known estrogen mimic and endocrine disruptor, has been linked to animal and human disorders. However, the detailed mechanism(s) by which DDT affects cellular physiology remains incompletely defined.

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