Akt Activation Is Responsible for Enhanced Migratory and Invasive Behavior of Arsenic-Transformed Human Bronchial Epithelial Cells | Zendy

Zhishan Wang | Zendy; Junling Yang | Zendy; Theresa Fisher | Zendy; Hua Xiao | Zendy; Yiguo Jiang | Zendy; Chengfeng Yang | Zendy

Open Access

Akt Activation Is Responsible for Enhanced Migratory and Invasive Behavior of Arsenic-Transformed Human Bronchial Epithelial Cells

Author(s) -

Zhishan Wang,

Junling Yang,

Theresa Fisher,

Hua Xiao,

Yiguo Jiang,

Chengfeng Yang

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104061

Subject(s) - protein kinase b , cell migration , pi3k/akt/mtor pathway , small interfering rna , gene knockdown , cancer research , microbiology and biotechnology , epithelial–mesenchymal transition , cell , chemistry , carcinogenesis , matrigel , biology , signal transduction , downregulation and upregulation , cell culture , transfection , cancer , biochemistry , genetics , gene

Arsenic is one of the most common environmental contaminants. Long-term exposure to arsenic causes human bronchial epithelial cell (HBEC) malignant transformation and lung cancer. However, the mechanism of arsenic lung carcinogenesis is not clear, and the migratory and invasive properties of arsenic-transformed cells (As-transformed cells) have rarely been studied.

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