Effects of Di(2-ethylhexyl) Phthalate (DEHP) on Female Fertility and Adipogenesis in C3H/N Mice | Zendy

Juliane-Susanne Schmidt | Zendy; Kristina Schaedlich | Zendy; N. Fiandanese | Zendy; Paola Pocar | Zendy; Bernd Fischer | Zendy

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Effects of Di(2-ethylhexyl) Phthalate (DEHP) on Female Fertility and Adipogenesis in C3H/N Mice

Author(s) -

Juliane-Susanne Schmidt,

Kristina Schaedlich,

N. Fiandanese,

Paola Pocar,

Bernd Fischer

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1104016

Subject(s) - phthalate , endocrinology , medicine , offspring , adipose tissue , adiponectin , biology , lactation , leptin , lipid metabolism , litter , obesity , pregnancy , chemistry , insulin resistance , organic chemistry , genetics , agronomy

Di(2-ethylhexyl) phthalate (DEHP) and its metabolites are known to affect lipid metabolism and adipogenesis, mainly by activation of peroxisome proliferator-activated receptors (PPARs). Exposure to DEHP has been linked with testicular impairment and male subfertility. However, the effects of DEHP on female reproductive health and metabolism have not been studied in detail.

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