Identification of Phthalates in Medications and Dietary Supplement Formulations in the United States and Canada | Zendy

Katherine E. Kelley | Zendy; Sonia Hernández–Dı́az | Zendy; Erica L. Chaplin | Zendy; Russ Hauser | Zendy; Allen A. Mitchell | Zendy

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Identification of Phthalates in Medications and Dietary Supplement Formulations in the United States and Canada

Author(s) -

Katherine E. Kelley,

Sonia Hernández–Dı́az,

Erica L. Chaplin,

Russ Hauser,

Allen A. Mitchell

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103998

Subject(s) - phthalate , diethyl phthalate , drug , excipient , population , cosmetics , medicine , pharmacology , toxicology , chemistry , environmental health , biology , organic chemistry

In animal studies, some ortho-phthalates, including di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP), have been shown to be reproductive and developmental toxicants. Human studies show widespread population exposure to background levels of phthalates. Limited evidence suggests that particularly high exposure levels may result from orally ingested medicinal products containing phthalates as excipients (inactive ingredients).

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