Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α | Zendy

Zhi-Guo Sheng | Zendy; BenZhan Zhu | Zendy

Open Access

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Author(s) -

Zhi-Guo Sheng,

BenZhan Zhu

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103781

Subject(s) - gper , estrogen receptor , mapk/erk pathway , cell growth , microbiology and biotechnology , creb , biology , signal transduction , chemistry , transcription factor , biochemistry , gene , genetics , cancer , breast cancer

Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve activation of ERs.

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