Maternal Exposure to Polycyclic Aromatic Hydrocarbons and 5’-CpG Methylation of Interferon-γ in Cord White Blood Cells | Zendy

WanYee Tang | Zendy; Linda Levin | Zendy; Glenn Talaska | Zendy; Yuk Yin Cheung | Zendy; Julie B. Herbstman | Zendy; Deliang Tang | Zendy; Rachel L. Miller | Zendy; Frederica P. Perera | Zendy; ShukMei Ho | Zendy

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Maternal Exposure to Polycyclic Aromatic Hydrocarbons and 5’-CpG Methylation of Interferon-γ in Cord White Blood Cells

Author(s) -

WanYee Tang,

Linda Levin,

Glenn Talaska,

Yuk Yin Cheung,

Julie B. Herbstman,

Deliang Tang,

Rachel L. Miller,

Frederica P. Perera,

ShukMei Ho

Publication year - 2012

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103744

Subject(s) - cord blood , dna methylation , epigenetics , cpg site , methylation , promoter , immunology , biology , andrology , microbiology and biotechnology , medicine , gene expression , gene , genetics

Maternal factors are implicated in the onset of childhood asthma. Differentiation of naïve CD4+ T lymphocytes into pro-allergic T-helper 2 cells induces interleukin (IL)4 expression and inhibits interferon (IFN)γ expression accompanied by concordant methylation changes in the promoters of these genes. However, it has yet to be established whether maternal exposure to polycyclic aromatic hydrocarbons (PAHs) can alter these gene promoters epigenetically during fetal development.

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