Seasonal Variation in TP53 R249S -Mutated Serum DNA with Aflatoxin Exposure and Hepatitis B Virus Infection | Zendy

Stéphanie Villar | Zendy; Emilie Le RouxGoglin | Zendy; Doriane Gouas | Zendy; Amelie Plymoth | Zendy; Gilles Ferro | Zendy; Mathieu Boniol | Zendy; Myriam Lereau | Zendy; Ebrima Bah | Zendy; Andrew J. Hall | Zendy; Christopher P. Wild | Zendy; Maimuna Mendy | Zendy; Heléne Norder | Zendy; Marianne A. B. van der Sande | Zendy; Hilton Whittle | Zendy; Marlin D. Friesen | Zendy; John D. Groopman | Zendy; Pierre Hainaut | Zendy

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Seasonal Variation in TP53 R249S -Mutated Serum DNA with Aflatoxin Exposure and Hepatitis B Virus Infection

Author(s) -

Stéphanie Villar,

Emilie Le RouxGoglin,

Doriane Gouas,

Amelie Plymoth,

Gilles Ferro,

Mathieu Boniol,

Myriam Lereau,

Ebrima Bah,

Andrew J. Hall,

Christopher P. Wild,

Maimuna Mendy,

Heléne Norder,

Marianne A. B. van der Sande,

Hilton Whittle,

Marlin D. Friesen,

John D. Groopman,

Pierre Hainaut

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103539

Subject(s) - hepatocellular carcinoma , hbsag , hepatitis b virus , hbeag , medicine , asymptomatic , virology , viral load , asymptomatic carrier , immunology , virus , gastroenterology

Chronic hepatitis B virus (HBV) infection and dietary aflatoxin B1 (AFB1) exposure are etiological factors for hepatocellular carcinoma (HCC) in countries with hot, humid climates. HCC often harbors a TP53 (tumor protein p53) mutation at codon 249 (R249S). In chronic carriers, 1762T/1764A mutations in the HBV X gene are associated with increased HCC risk. Both mutations have been detected in circulating cell-free DNA (CFDNA) from asymptomatic HBV carriers.

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