Global Methylation in Exposure Biology and Translational Medical Science | Zendy

Heather H. Nelson | Zendy; Carmen J. Marsit | Zendy; Karl T. Kelsey | Zendy

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Global Methylation in Exposure Biology and Translational Medical Science

Author(s) -

Heather H. Nelson,

Carmen J. Marsit,

Karl T. Kelsey

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103423

Subject(s) - translational science , methylation , translational research , translational medicine , computational biology , biology , medicine , genetics , microbiology and biotechnology , pathology , gene

Many groups are actively investigating how the epigenetic state relates to environmental exposures and development of disease, including cancer. There are myriad choices for capturing and measuring the epigenetic state of a tissue, ranging from assessing the total methyl-CpG content to array-based platforms that simultaneously probe hundreds of thousands of CpG loci. There is an emerging literature that uses CpG methylation at repetitive sequences, including LINE-1 (long interspersed nuclear element-1) elements, to capture the epigenomic state.

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