Environmental Impact on Vascular Development Predicted by High-Throughput Screening | Zendy

Nicole Kleinstreuer | Zendy; Richard Judson | Zendy; David M. Reif | Zendy; Nisha S. Sipes | Zendy; Amar V. Singh | Zendy; Kelly J. Chandler | Zendy; Rob DeWoskin | Zendy; David J. Dix | Zendy; Robert J. Kavlock | Zendy; Thomas B. Knudsen | Zendy

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Environmental Impact on Vascular Development Predicted by High-Throughput Screening

Author(s) -

Nicole Kleinstreuer,

Richard Judson,

David M. Reif,

Nisha S. Sipes,

Amar V. Singh,

Kelly J. Chandler,

Rob DeWoskin,

David J. Dix,

Robert J. Kavlock,

Thomas B. Knudsen

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1103412

Subject(s) - high throughput screening , biology , computational biology , in vitro toxicology , in vivo , microbiology and biotechnology , bioinformatics

Understanding health risks to embryonic development from exposure to environmental chemicals is a significant challenge given the diverse chemical landscape and paucity of data for most of these compounds. High-throughput screening (HTS) in the U.S. Environmental Protection Agency (EPA) ToxCast™ project provides vast data on an expanding chemical library currently consisting of > 1,000 unique compounds across > 500 in vitro assays in phase I (complete) and Phase II (under way). This public data set can be used to evaluate concentration-dependent effects on many diverse biological targets and build predictive models of prototypical toxicity pathways that can aid decision making for assessments of human developmental health and disease.

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