Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers | Zendy

Neil E. Alexis | Zendy; John C. Lay | Zendy; Angela Haczku | Zendy; Henry Gong | Zendy; William S. Linn | Zendy; Milan J. Hazucha | Zendy; Brad Harris | Zendy; Ruth TalSinger | Zendy; David B. Peden | Zendy

Open Access

Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers

Author(s) -

Neil E. Alexis,

John C. Lay,

Angela Haczku,

Henry Gong,

William S. Linn,

Milan J. Hazucha,

Brad Harris,

Ruth TalSinger,

David B. Peden

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10981

Subject(s) - neutrophilia , immunology , medicine , fluticasone propionate , sputum , inflammation , exhaled nitric oxide , immune system , pharmacology , systemic inflammation , asthma , pathology , tuberculosis

Ozone exposure induces airway neutrophilia and modifies innate immune monocytic cell-surface phenotypes in healthy individuals. High-dose inhaled corticosteroids can reduce O(3)-induced airway inflammation, but their effect on innate immune activation is unknown.

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