Mechanism of Selenium-Induced Inhibition of Arsenic-Enhanced UVR Carcinogenesis in Mice | Zendy

Fredric J. Burns | Zendy; Toby G. Rossman | Zendy; Katherine Vega | Zendy; Ahmed Uddin | Zendy; Stefan Vogt | Zendy; Barry Lai | Zendy; Richard J. Reeder | Zendy

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Mechanism of Selenium-Induced Inhibition of Arsenic-Enhanced UVR Carcinogenesis in Mice

Author(s) -

Fredric J. Burns,

Toby G. Rossman,

Katherine Vega,

Ahmed Uddin,

Stefan Vogt,

Barry Lai,

Richard J. Reeder

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10978

Subject(s) - hairless , selenium , arsenite , arsenic , carcinogenesis , sodium arsenite , dmba , chemistry , epidermis (zoology) , skin cancer , biology , biochemistry , cancer , anatomy , genetics , organic chemistry , gene

Hairless mice that ingested arsenite in drinking water exhibited more than a 5-fold enhancement of ultraviolet radiation (UVR) carcinogenesis, whereas arsenite alone was carcinogenically inactive. Dietary organoselenium blocked the cancer enhancement effect of arsenic but not cancer induction by UVR.

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