Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies | Zendy

Marc-André Verner | Zendy; Michel Charbonneau | Zendy; Lizbeth LópezCarrillo | Zendy; Sami Haddad | Zendy

Open Access

Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies

Author(s) -

Marc-André Verner,

Michel Charbonneau,

Lizbeth LópezCarrillo,

Sami Haddad

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10917

Subject(s) - physiologically based pharmacokinetic modelling , pharmacokinetics , medicine , physiology , computational biology , bioinformatics , pharmacology , biology

Despite experimental evidence, most epidemiologic studies to date have not supported an association between exposure to persistent organic pollutants (POP) and breast cancer incidence in humans. This may be attributable to difficulties in estimating blood/tissue POP concentration at critical time periods of carcinogenesis.

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