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Drinking-Water Arsenic Exposure Modulates Gene Expression in Human Lymphocytes from a U.S. Population
Author(s) -
Angeline S. Andrew,
David A. Jewell,
Rebecca A. Mason,
Michael L. Whitfield,
Jason H. Moore,
Margaret R. Karagas
Publication year - 2008
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.10861
Subject(s) - arsenic , biology , population , immunology , immune system , arsenic toxicity , lymphocyte , microarray , gene expression , gene , medicine , genetics , chemistry , environmental health , organic chemistry
Arsenic exposure impairs development and can lead to cancer, cardiovascular disease, and diabetes. The mechanism underlying these effects remains unknown. Primarily because of geologic sources of contamination, drinking-water arsenic levels are above the current recommended maximum contaminant level of 10 microg/L in the northeastern, western, and north central regions of the United States.

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