Styrene Trimer May Increase Thyroid Hormone Levels via Down-Regulation of the Aryl Hydrocarbon Receptor (AhR) Target Gene UDP-Glucuronosyltransferase | Zendy

Yukie Yanagiba | Zendy; Yuki Ito | Zendy; Osamu Yamanoshita | Zendy; Shuyun Zhang | Zendy; Gen Watanabe | Zendy; Kazuyoshi Taya | Zendy; Chun Mei Li | Zendy; Yuko Inotsume | Zendy; Michihiro Kamijima | Zendy; Frank J. Gonzalez | Zendy; Tamie Nakajima | Zendy

Open Access

Styrene Trimer May Increase Thyroid Hormone Levels via Down-Regulation of the Aryl Hydrocarbon Receptor (AhR) Target Gene UDP-Glucuronosyltransferase

Author(s) -

Yukie Yanagiba,

Yuki Ito,

Osamu Yamanoshita,

Shuyun Zhang,

Gen Watanabe,

Kazuyoshi Taya,

Chun Mei Li,

Yuko Inotsume,

Michihiro Kamijima,

Frank J. Gonzalez,

Tamie Nakajima

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10724

Subject(s) - aryl hydrocarbon receptor , medicine , endocrinology , chemistry , cytochrome p450 , thyroid , cyp2e1 , endocrine system , hormone , biology , metabolism , biochemistry , gene , transcription factor

Styrene trimers (STs) are polystyrene-container-eluted materials that are sometimes detected in packaged foods. Although the possible endocrine-disrupting effects of STs, such as estrogenic activities, have been reported, their potential thyroid toxicity, such as that caused by the related endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has not been studied in detail.

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