Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ | Zendy

Hiroyuki Okada | Zendy; Takatoshi Tokunaga | Zendy; Xiaohui Liu | Zendy; Sayaka Takayanagi | Zendy; Ayami Matsushima | Zendy; Yasuyuki Shimohigashi | Zendy

Open Access

Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ

Author(s) -

Hiroyuki Okada,

Takatoshi Tokunaga,

Xiaohui Liu,

Sayaka Takayanagi,

Ayami Matsushima,

Yasuyuki Shimohigashi

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10587

Subject(s) - endocrine disruptor , chemistry , luciferase , estrogen receptor , bisphenol a , reporter gene , ligand binding assay , estrogen receptor alpha , estrogen , biochemistry , receptor , pharmacology , endocrinology , medicine , biology , gene expression , endocrine system , gene , transfection , hormone , organic chemistry , cancer , breast cancer , epoxy

Various lines of evidence have shown that bisphenol A [BPA; HO-C6H4-C(CH3)2-C6H4-OH] acts as an endocrine disruptor when present in very low doses. We have recently demonstrated that BPA binds strongly to human estrogen-related receptor-gamma (ERR-gamma ) in a binding assay using [3H]4-hydroxytamoxifen ([3H]4-OHT). We also demonstrated that BPA inhibits the deactivation activity of 4-OHT.

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