The Protective Mechanism of Antioxidants in Cadmium-Induced Ototoxicity in Vitro and in Vivo
Author(s) -
Sujin Kim,
HyunJa Jeong,
NohYil Myung,
Min-Chol Kim,
JeongHan Lee,
HongSeob So,
Raekil Park,
HyungMin Kim,
JaeYoung Um,
SeungHeon Hong
Publication year - 2008
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.10467
Subject(s) - mapk/erk pathway , caspase , reactive oxygen species , ototoxicity , microbiology and biotechnology , apoptosis , signal transduction , chemistry , pharmacology , toxicity , viability assay , programmed cell death , biology , biochemistry , chemotherapy , cisplatin , genetics , organic chemistry
Several heavy metals have been shown to have toxic effects on the peripheral and central auditory system. Cadmium (Cd2+) is an environmental contaminant showing a variety of adverse effects. Given the current rate of release into the environment, the amount of Cd2+ present in the human body and the incidence of Cd2+-related diseases are expected to increase.
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