Embryonic Exposure to Domoic Acid Increases the Susceptibility of Zebrafish Larvae to the Chemical Convulsant Pentylenetetrazole | Zendy

Jessica A. Tiedeken | Zendy; John S. Ramsdell | Zendy

Open Access

Embryonic Exposure to Domoic Acid Increases the Susceptibility of Zebrafish Larvae to the Chemical Convulsant Pentylenetetrazole

Author(s) -

Jessica A. Tiedeken,

John S. Ramsdell

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10344

Subject(s) - in ovo , convulsant , domoic acid , neurotoxin , zebrafish , biology , danio , status epilepticus , epilepsy , embryo , pharmacology , chemistry , toxicology , endocrinology , biochemistry , neuroscience , microbiology and biotechnology , receptor , gene , toxin

Domoic acid (DA) is a neurotoxin produced by diatoms of the genus Pseudo-nitzschia that targets the limbic system to induce tonic-clonic seizures and memory impairment. In utero DA exposure of mice leads to a reduction in seizure threshold to subsequent DA exposures in mid-postnatal life, and similar studies have shown neurotoxic effects in rats that were delayed until adolescence.

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