Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort | Zendy

Teresa Chahine | Zendy; Andrea Baccarelli | Zendy; Augusto A. Litonjua | Zendy; Robert O. Wright | Zendy; Helen Suh | Zendy; Diane R. Gold | Zendy; David Sparrow | Zendy; Pantel Vokonas | Zendy; Joel Schwartz | Zendy

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Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort

Author(s) -

Teresa Chahine,

Andrea Baccarelli,

Augusto A. Litonjua,

Robert O. Wright,

Helen Suh,

Diane R. Gold,

David Sparrow,

Pantel Vokonas,

Joel Schwartz

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10318

Subject(s) - heart rate variability , oxidative stress , medicine , cohort , confounding , exhalation , endocrinology , heart rate , cardiology , physiology , blood pressure , radiology

We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 microm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sectional analysis of the Normative Aging Study, an elderly cohort. We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter.

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