Unique Bisphenol A Transcriptome in Prostate Cancer: Novel Effects on ERβ Expression That Correspond to Androgen Receptor Mutation Status | Zendy

Janet K. Hess-Wilson | Zendy; Siobhan Webb | Zendy; Hannah K. Daly | Zendy; YuetKin Leung | Zendy; Joanne Boldison | Zendy; Clay E.S. Comstock | Zendy; Maureen A. Sartor | Zendy; ShukMei Ho | Zendy; Karen E. Knudsen | Zendy

Open Access

Unique Bisphenol A Transcriptome in Prostate Cancer: Novel Effects on ERβ Expression That Correspond to Androgen Receptor Mutation Status

Author(s) -

Janet K. Hess-Wilson,

Siobhan Webb,

Hannah K. Daly,

YuetKin Leung,

Joanne Boldison,

Clay E.S. Comstock,

Maureen A. Sartor,

ShukMei Ho,

Karen E. Knudsen

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10283

Subject(s) - prostate cancer , androgen receptor , cancer research , transcriptome , biology , estrogen receptor , mutation , germline mutation , cancer , endocrinology , medicine , microbiology and biotechnology , gene expression , genetics , gene , breast cancer

Prostatic adenocarcinomas are dependent on androgen receptor (AR) activity for growth and progression, and therapy for disseminated disease depends on ablation of AR activity. Recurrent tumors ultimately arise wherein AR has been re-activated. One mechanism of AR restoration is via somatic mutation, wherein cells containing mutant receptors become susceptible to activation by alternative ligands, including bisphenol A (BPA). In tumors with specific AR mutations, BPA promotes therapeutic bypass, suggesting significant negative impact to the clinical management of prostate cancer.

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